Intellectual Property

HAPLOID CHROMOSOME ANALYSIS PATENTS

A. Genetic Analysis

METHODS FOR GENE MAPPING AND HAPLOTYPING

Application No: PCT/AU2006/001836
Publication No: WO2007/062486

This invention describes methods for providing a definitive haplotype, as distinct methods that provide only for an inferred haplotype. The methods provide for substantially isolated haploid segment, and for obtaining nucleotide sequence information that haploid segment, which eliminates the problem of incorrect or misleading concerning the phase of two or more loci within a haplotype. The method provides guarantee of strictly cis-phase associations by use of a substantially haploid segment as starting material for sequence analysis

IN SITU METHODS FOR GENE MAPPING AND HAPLOTYPING

Application No: PCT/AU2008/000808
Publication No: WO2008/148161

This invention describes the use of non-physical methods such as FISH/specific chromosome probes to determine true haplotypes.

B. Epigenetic Analysis

EPIGENETIC METHODS

Application No: PCT/AU2008/00806
Publication No: WO2008/148159

This invention describes methods for investigating epigenetic characteristics of the haploid state of an organism.

SEQUENCE ANALYSIS PATENTS

Chromosome Megabase Subregion Identification, Typing
& Capture of Highly Polymorphic Sequence.

METHODS AND PROBES FOR IDENTIFYING A NUCLEOTIDE SEQUENCE

Application No: PCT/AU2006/001740
Publication No: WO2007/056825

This invention describes a method to identify and capture all known single nucleotide polymorphisms (SNPs) over any chosen probe length, with overlap to ensure redundancy, and therefore resolution of the multiple SNPs in population DNA samples over megabase distances

MICROARRAY METHODS

Application No: PCT/AU2006/001977
Publication No: WO2007/076577

This invention concerns methods for the detection of specific nucleic acid sequences from test samples containing large numbers of such sequences, typical of those derived from the full genetic complement of mRNAs or genes in a prokaryotic or eukaryotic cell. The invention relates particularly to methods for selecting probes for use in microarray applications, and describes the hybridization conditions required for the microarray probe solution to High-SNP density sequence analysis. It includes technical and genetic strategies for gene sequence assignment independent of hybridization conditions.

NOTE: All patent applications have been filed in Canada, China, Europe, Japan and USA.